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pentobarbital will lessen the level or outcome of ethotoin by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Watch.pentobarbital will lessen the level or effect of buprenorphine subdermal implant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Closely. Watch clients by now on buprenorphine subdermal impl